Chemical X-Traction is a cartoon fighting game where kids are challenged to join Bubbles, Blossom and Buttercup as they battle Mojo Jojo and other notorious Townsville villains in an effort to stop Mojo’s reign of terror in Townsville.
As the game begins, The Powerpuff Girls are in their kitchen having just finished baking a great big pie. They rest the pie on the windowsill so it can cool off, but when Blossom and Buttercup leave, Bubbles decides that the pie needs something extra-special - a dose of Chemical X. She goes down to the lab, gets the X, and pours a healthy dose into the pie before leaving it to cool. Little does she know that Mojo Jojo is lurking outside the window just waiting for such an opportunity. Mojo Jojo quickly swipes the super pie and runs off with it. Mojo Jojo then calls together the villains of Townsville and gives them all pieces of the pie filled with Chemical X so that they can finally be super powered and beat those pesky Powerpuff Girls.
Meanwhile at home, the girls discover their pie has been snatched and they immediately know only one villain would do such a fiendish thing—Mojo Jojo. Blossom and Buttercup think this is a pretty foolish thing to steal until Bubbles tells them about the Chemical X she added to the mix. The girls must hunt down the villains, going from location to location all over Townsville, beating up the bad guys and knocking the Chemical X out of them. Using their special powers, the girls bring peace back to Townsville.